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Vascular alterations, such as inflammation, remodeling, stiffness, calcification, and atherosclerosis, may play a role

It does not invalidate the research, but it does mean human extrapolation should be conservative

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Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity