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In addition to the primary outcome of SELECT, nominally statistically significant risk reductions were also seen in secondary efficacy endpoints, including heart failure composite endpoint, all-cause mortality, coronary revascularizations, sustained weight loss for 104 weeks, a 5-point nephropathy composite endpoint, and patients developing biochemical diabetes (at least one post-randomization glycated hemoglobin [HbA 1c ] 6.5%) [21]

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