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To see whether an elevation in H 2 S levels affected persulfidation, we investigated cardiac ischaemia, when the lack of oxygen and consequent reduction of the mitochondrial Coenzyme Q pool prevents the oxidation of H 2 S by mitochondrial SQOR and is thus thought to lead to the accumulation of H 2 S 12,13

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At the highest doses used for obesity treatment (2.4 mg semaglutide, 15 mg tirzepatide), the medication may overwhelm certain regulatory mechanisms and produce paradoxical sensitization