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Nutritional folate deficiency combined more or less with the C677T MTHFR mutation may play an important role in basal hyperhomocysteinemia, whereas vitamin B 6 deficiency and heterozygosity for a CBS defect may only contribute to abnormal increment of postmethionine-load homocysteine levels (Ubbink et al, 1996)

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Dalton TP, Chen Y, Schneider SN, Nebert DW, Shertzer HG