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Researchers believe GIP co-activation may have a protective effect on the GI tract, explaining why dual and triple agonists are often better tolerated than single-agonist Semaglutide (which has 44% nausea rates)

32 The primary outcome for the trial was the first occurrence of a major adverse cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)

Most people do semaglutide injections once a week, and the abdomen, thigh, or upper arm are the most common injection sites

Ive tried everything beforethis is the first thing that worked. Jessica R

The intensity and duration of these effects vary widely between individuals and can influence both tolerance and adherence over time