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Freezing reconstituted peptide solutions can cause ice crystals to form that damage the protein structure

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They are also typically less expensive than injectable treatments

Note that the TB-500 name has historically been applied both to the full 43-residue protein and, as documented by Ho and colleagues (J Chromatogr A, 2012), to preparations containing only the LKKTETQ heptapeptide

Heterogeneity of gastric histology and function in food cobalamin malabsorption: absence of atrophic gastritis and achlorhydria in some patients with severe malabsorption