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Br J Psychiatry
FEBS J 277:50865096 Mandal PK, Ersland L (2019) Editorial: Predictive imagable biomarkers for neurodegenerative and neurodevelopmental diseases
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One important feature may be neurogenic claudication which is the onset and worsening of pain, weakness, numbness, tingling, heaviness, or fatigue sensation in the hips, buttocks, and lower limbs that is exacerbated with standing and walking, and improved with sitting or leaning forward on an object such as a shopping cart or walker
These signaling alterations result in reduced osteoblast maturation and decreased osteoblast numbers
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