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Typically, brightening products are meant to target discoloration in the skin caused by factors like sun damage and acne scarring, and to reveal more vibrant, healthy-looking skin

phase 2 trial data confirm gastrointestinal side effects are common, though heartburn was not consistently itemised as a standalone adverse event

Retatrutide is designed to activate three hormone receptor pathways involved in appetite, glucose handling, and energy balance

Treatment starts with 0.25 mg weekly for 4 weeks as an initiation dose only (not for glycaemic maintenance), then increases to 0.5 mg weekly