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The reasoning: hormonal dysfunction in adipose tissue and hyperinsulinemia from insulin resistance can act similarly to reproductive hormones, directly contributing to the hyperandrogenism that defines PCOS

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PMCID: PMC13028870

In this light, we want to emphasize how a timely and appropriately regulated manipulation of the KEAP1-NRF2 system is crucial to develop effective and safe therapeutic treatment for neurodegenerative diseases, such as ALS, which involve an imbalance in the OS response

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