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A further clinical trial called SELECT found that Wegovy produced clinically significant weight loss after 208 weeks
doi: 10.1067/S0022-3476(03)00386-X 16 MuscogiuriGBarreaLFaggianoFMaiorinoMIParrilloMPuglieseGet al
For patients with a body mass index (BMI) over 35 kg/m 2 , guidance 3 recommends a greater weight loss of 15 to 20% for sustained improvement in comorbidity
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Thus, drugs that target GIP, GLP-1, or GLP-2 receptor signalling pathways could be employed for treating bone diseases
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