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Animal studies have shown that 95% hyperoxia substantially enhanced cellular ROS generation, increased apoptosis, induced TRX-1 and TRXR-1 expression while the TRXR-1 activity was reduced

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Zhu G, Yin Y, Xiao C-L, Mao R-J, Shi B-H, Jie Y, Wang Z-W (2015) Serum DHEAS levels are associated with the development of depression

These diverge, and they diverge in a predictable direction: a preparation that has partially dissociated or partially denatured usually keeps most of its antibody-binding surfaces intact while losing activity, so the immunoassay reads close to expectation while the biological readout has fallen

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