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Liraglutide can downregulate the expression of HMGB-1 , RAGE , and TLR-4 in the livers of mice, causing a reduction in p38 MAPK, p-NF-B p65, TNF-, and other inflammatory factors

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C-met binding was examined at two HGF-doses (250 ng/ml and 500 ng/ml in PBS) by sandwich ELISA-like assay on recombinant c-met-Fc chimera as in Figure 1e, and significant changes in optical absorbance subtracted by a baseline level (negative control without HGF, bar 1 ) were depicted in Figure 2a (left column)