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Image Credit: DukiPH / Shutterstock.com Introduction Orforglipron is an orally bioavailable next-generation glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) that has emerged as a potential alternative to injectable agents like semaglutide based on early Phase 1, 2, and 3 clinical trials demonstrating glucose-lowering and weight-loss efficacy without the need for injection-based delivery
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Building on earlier findings that pericytes constrict coronary capillaries at the onset of ischaemia, when the heart receives insufficient oxygen-rich blood, the team investigated whether GLP-1 could help reverse these blockages
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