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Due to the instability of vitamin B12, by mixing in other drugs, a loss of effect of the vitamin may occur
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The SiteMap tool [33, 34] was employed to identify potential drug binding sites on the TBC1D15 protein, which were chosen based on their proximity to the area which also interacts with the Rab7 protein
The most common causes include B12 supplementation (particularly injections), liver disease releasing stored B12, haematological disorders increasing B12-binding proteins, and chronic kidney disease reducing B12 excretion
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