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No impact at all on the patients life (01), minimal effect on the patients life (25), moderate impact on the patients life (610), very high impact on the patients life (1120), extremely high impact on the patients life (2130) Global Esthetic Improvement Score (GAIS) assessment Patient and physician assessments were performed before treatment at 4 and 12 weeks after the end of treatment using the Global Esthetic Improvement Score (GAIS), which is a five-point scale: 1-very much improved

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was supported by the National Science Technology Council, Taiwan: NSTC107-2923-M-006-002-MY3 (M-ERA.NET2 nanoPD)

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