Peptide 5 is shown in stick representation with carbon, nitrogen and oxygen atoms coloured purple, blue and red respectively
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A C20 fatty diacid moiety facilitates albumin binding, protecting the peptide from enzymatic degradation and extending its half-life to approximately 6 days in research models a structural feature that distinguishes it from shorter-acting GLP-1 analogs and supports weekly administration protocols in preclinical study designs
TRIUMPH-4 (obesity with knee osteoarthritis) reported positive results in late last year
As mentioned earlier, given that GLP-1RAs have a regulatory impact on these immune cells, they could potentially serve as a therapeutic target for RA