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16 In terms of treatment, dietary Asp supplementation has not been as effective as expected, and artificially elevated blood Asn may affect the absorption of other amino acids due to competition for cotransporters

Chemistry & Biodiversity , 17 (5), e2000012

Rampant oxidative stress resulting from glutathione insufficiency may contribute to the pathogenesis of several neurological and neurodegenerative disorders, type 2 diabetes, cancer, heart attack and stroke.45 Supplementation may be warranted in order to correct depleted states and augment endogenous glutathione synthesis under circumstances when higher levels may be beneficial

why the benefit is largest in the stressed and nil in the calm

Relevant to laboratory models involving glutathione availability, redox balance, oxidative stress response, and cellular defense systems