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Redox-buffering systems, including GPX4, 35,36 AIF family member 2 (AIFM2, also known as ferroptosis suppressor protein 1 (FSP1)), 37,38,39,40,41 and endogenous radical-trapping molecules such as glutathione, 35,42,43 7-dehydrocholesterol, 44,45,46 and hydropersulfides, 47,48,49 together with membrane damage repair machinery such as the endosomal sorting complex required for transport III (ESCRT-III), 50,51 do not operate as simple on-off switches