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This isn't just theory
[3] Dosing of hydroxocobalamin should be individualized based on the severity of vitamin B deficiency and clinical response
This was a recommendation both in the James Lind Alliance Priority Setting Partnership which PAS initiated and funded and in the NICE Guideline on B12 Deficiency which PAS initiated
Digestive issues may further reduce the effectiveness
Citation219 However, the starting viscosity of the solution may impact instrument performance, including process time and extent of buffer exchange (unpublished data)
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