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Most clinical studies have examined these substances independently rather than in combination, so the safety profile and potential synergistic or additive effects remain inadequately characterised
It requires platforms and services that operate in this space to build the supporting resources
J Child Neurol 1998;13:546-9
Compounds used for in vivo experiments were further purified by size exclusion chromatography using a HiLoad Superdex 200 pg column (GE Healthcare) and further characterised for endotoxin level using the LAL Kinetic-QCL (Lonza) and integrity by LC/MS using an Acquity UPLC system coupled to a Synapt G1 mass spectrometer (Waters)
Support multiple reputable generic/biosimilar manufacturers to avoid over-dependence on one supplier.[7] This would improve the reliability of manufacturing and distribution systems
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