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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)
doi: 10.1590/s1677-5538.ibju.2024.9917 25 FuPEpshteinYRamchandranRMascarenhasJBCressAEJacobsonJet al
Dev Neurosci
Endocrinology 152 , 13471354 (2011)
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