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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

The pre-specified primary efficacy analyses included data from study 1 and pooled data from studies 2 and 3, regardless of glycemic rescue or treatment discontinuation

However, it remains unclear whether improvements result primarily from appetite suppression, altered reward processing, or both

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Specifically, IRPs binding to IREs at the 5-UTR suppress translation of ferritin, FPN1, and amyloid precursor protein (APP), while IRP binding at the 3-UTR stabilizes mRNAs of TfR1 and DMT1, thereby promoting iron uptake under conditions of deficiency (Mai et al., 2023)