or MCE, HY-108467) was diluted in sterile saline and injected at the indicated concentrations
In recent years, natural polyphenols have shown great potential in combating cisplatin ototoxicity due to their powerful antioxidant, anti-inflammatory and anti-apoptotic properties.A variety of polyphenolic compounds, such as resveratrol, curcumin, quercetin, etc., can effectively attenuate the damage of cisplatin on Corti organs, spiral ganglion neurons and vascular striatum by scavenging free radicals, inhibiting the release of inflammatory factors, and regulating the expression of apoptosis-related proteins
Liposomal glutathione supplements have also become increasingly popular due to their enhanced delivery systems, though research in this area continues to evolve
GPx3 upregulated in clear-cell ovarian cancer may promote chemotherapeutic resistance (94)
Considering that highly sensitive xCT inhibitors and cystine deprivation can induce ferroptosis, several ferroptosis-inducing agents have been developed [15,35,42]