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Possible side effects In studies using higher-dose extracts, some people have reported mild nausea, dizziness, a slight increase in appetite, and feeling more sedated than expected

doi: 10.1177/2040622319862691 152 OMahonyS

As previously reported, in these trials gastrointestinal events were the most common adverse effects in patients receiving orforglipron, consistent with the GLP-1 receptor agonist class [25, 26]

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When this develops, you experience numbness and sometimes pain in the hands and feet, and since these nerves are also responsible for sending messages to the brain regarding temperature sensation, your hands and feet may feel cold, Dr