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GSH is the predominant intracellular form, which acts as a strong antioxidant and defends against toxic compounds and xenobiotics

Mitochondrial dysfunction and the resulting oxidative stress in cochlear cells may arise from inherited mitochondrial DNA (mtDNA) mutations, which are associated with aminoglycoside-induced ototoxicity and hereditary hearing loss

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Together with their antioxidant roles against reactive oxygen species (ROS) and reactive nitrogen species (RNS), NAC and HPN-07whose structural analog is -phenyl-N-tert-butylnitrone (PBN)have each been reported to promote neurogenesis through proposed mechanisms involving the activation of the Rasextracellular signal-regulated kinase (ERK) and protein kinase C (PKC) pathways 30,31,32

Chen, W