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Semaglutide works by: Enhancing insulin secretion in response to elevated blood glucose levels Suppressing glucagon release , which reduces glucose production by the liver Slowing gastric emptying , leading to prolonged feelings of fullness Acting on appetite centres in the brain , reducing hunger and food intake It is this combination of delayed gastric emptying and reduced appetite that contributes to weight loss in many patients

Several indirect mechanisms may explain why some patients report muscle pain or weakness while taking GLP-1 medications, even in the absence of direct myotoxicity

So less is always going to be more when it comes to things like alcohol