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Similarly, Cyp51a1 -/- knockout mice die around embryonic day 15, and the embryos exhibit several developmental malformations similar to ABS, such as skeletal malformations and heart defects

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Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

Further studies revealed that hyperandrogenemia may establish a self-amplifying mechanism by upregulating the expression of steroidogenic enzymes