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Diabetes Ther 16 , 813849 (2025)
However, these individuals are at high risk of weight rebound if they return to old habits or undergo a stressful situation, he adds
An effective oral alternative would eliminate all of this friction
They influence stability (how long the product remains potent), compatibility (whether ingredients interact with each other or with the syringe material), and tolerability (some excipients can cause injection site reactions in sensitive individuals)
For weight management, NICE recommends these medications as an adjunct to lifestyle modification in specialist weight management services, with specific BMI thresholds (typically 35 kg/m or 32.5 kg/m in certain ethnic groups) with comorbidities, and usually for time-limited periods (up to 2 years for semaglutide)
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