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From that standpoint, its probably more the variation in whats happening at the microbiome level as far as exposure to these compounds. Thats why the TMAO synthesis pathway has become one of the first gut microbiota targets for pharmaceutical interventions to prevent CVD,12 even though that pathway is quite complex

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These changes lead to the accumulation of damaged proteins in myocytes, thereby reducing their ability to adapt to physiological stress and increasing the risk of heart disease in old age

doi:10.12659/msm.897282 Wagh VD