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Research status Mostly preclinical evidence

For many individuals, oral B12 supplements are ineffective due to such underlying conditions as: Pernicious anemia : People with this condition lack intrinsic factor, a protein required for B12 absorption in the small intestine

14 JonitzA.LochnerK.TischerT.HansmannD.BaderR

Along with the flavin-like fluorescence emission, an intense peak in the mass spectrum of the bacterial extracts, corresponding to an m/z ratio of 376, suggests the presence of riboflavin as a significant component of the mixture (Figure 8)