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Retatrutide appeared to induce lean mass loss in similar proportions to GLP-1RAs alone, whereas PTT-A has shown robust fat reduction without significant decrease in muscle mass, highlighting the potential of selective multi-agonists to preserve skeletal muscle during weight loss [66, 67]

But Sarah Hampl, MD, FAAP, a spokesperson for the AAP and a pediatrician who helped author the obesity guidance, rebutted those criticisms

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Laboratory studies use the defined four-residue structure to investigate peptide-dependent changes in gene expression, enzyme activity and cellular ageing models

Paredes et al., 2021)