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Although most of the published studies suggest a modest beneficial effect, relatively few studies are well-controlled, the methods of assessment are not validated, and assessment may be insensitive to important changes induced by a variety of therapies, including L-carnitine itself

J Biol Chem 287(12):89208931

The osteogenic function of seeding cells is intricately linked to the osteoimmune microenvironment where they reside (Takayanagi, 2007)

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Intriguingly, recent research has shown that lactate is not only essential for efferocytosis but also for sustaining efferocytosis-induced macrophage proliferation, a process responsible for increasing the number of macrophages capable of performing continuous efferocytosis, thus contributing to the resolution of inflammation and tissue repair [87] (Fig