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doi: 10.1016/j.heliyon.2023.e21694 17 ZhaiYYeXHuFXuJGuoXZhuangYet al
No published clinical trials support twice-weekly dosing for weight loss or safety
However, genetic predisposition is one factor among manybaseline metabolic health, adherence, dose tolerance, and lifestyle context remain equally important determinants of real-world outcomes
As use of GLP-1 receptor agonists continues to expand, the integration of conventional clinical evidence with large-scale observational data may offer a more complete picture of how these therapies affect patients in routine practice
Both ER stress and amino acid starvation induce stress synergistically by activating ATF4 and ChaC1 is one of the downstream targets of ATF4
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