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This expansive impact includes the upregulation of genes responsible for cancer suppression, such as caspases, which play a pivotal role in apoptosis

It is possible that weight monitoring was a lower priority for individuals with normal weight, as suggested by the fact that nearly 80% of the population was overweight or obese at the time of switch to DOR and that a large proportion of DOR users were excluded due to the absence of weight measurement

doi: 10.1038/s41392-021-00800-3 18 CostaTJPotjeSRFraga-SilvaTFCDa Silva-NetoJABarrosPRRodriguesDet al

[1] The medication acts on receptors in the brain's appetite centers, particularly the hypothalamus, to reduce hunger and increase feelings of fullness after eating