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This can affect energy, mood, detoxification, and homocysteine levels

Therefore, Erastin ultimately decreases the amount of GSH

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Ferritin-targeted strategies remain largely underexplored in brain cancers and could represent a novel approach to induce ferroptosis in embryonic-origin tumors, such as glioblastoma (GBM) and medulloblastoma (MB), potentially sensitizing CSCs to conventional therapies by reducing their antioxidant capacity

They can catalyze oxidation of cysteine-containing or methionine-containing residues in co-dissolved peptides