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Potential theoretical benefits include: Body composition considerations : Tirzepatide promotes significant fat loss through appetite suppression and metabolic effects, while sermorelin might theoretically support lean muscle preservation through growth hormone stimulationpotentially mitigating the muscle loss sometimes observed with rapid weight reduction

Two other brand-name semaglutide drugs, Ozempic and Rybelsus, are not approved for weight loss but are often prescribed off-label for that use

Your clinician is doing a disservice to you if theyre prescribing a GLP-1 to you without also monitoring your weight and health goals, and any side effects you experience, she said

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Funding This study was supported by Natural Science Foundation of Guangdong Province (2021A1515012393), NSFC grant (82371692, 32170825), Key laboratory of functional and clinical translational medicine, Guangdong Provincial Sports Bureau Scientific Research Project (GDSS2024N007), and Guangdong Medical Science and Technology Research Foundation (A2023145)