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5.3 Safety and off-target effects Modulating the immune system and mitochondria can have unintended consequences
This is partly due to the ABCG2 efflux pump, which transports sulfasalazine out of cells, reducing its absorption and effectiveness [205]
Efficacy of oral long-term N-acetylcysteine for respiratory support: a meta-analysis of published double-blind, placebo-controlled clinical trials
mtDAMPs activate neutrophils and monocytes, which infiltrate tissues and release additional ROS and proteases, causing further mitochondrial damage and cell death
Thus, ferroptosis and other cellular processes involving phospholipid peroxidation can be regulated by controlling phospholipid peroxidation
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