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Normal and expected reactions include a brief stinging or burning sensation during or immediately after injection, mild redness or warmth at the injection site lasting a few minutes, and small temporary lumps that resolve within 30 to 60 minutes as the solution disperses through subcutaneous tissue
Potential endpoints include: Endothelial-cell viability Migration Tube-formation assays Growth-factor-associated measurements Matrix interaction Cell-junction markers Gene-expression changes Structural imaging Tube formation in a culture model does not independently establish blood-vessel growth, tissue repair, or clinical benefit
It includes only a specific part of the FOXO4 sequence crucial for interacting with p53
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