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Influence of glucagon-like peptide-1 receptor agonists on hepatic events in type 2 diabetes: a systematic review and meta-analysis

Petrov, M

A Mayo Clinic study in The Lancet [1] (2025) followed 400 postmenopausal women on tirzepatide for 12+ months: HRT + tirzepatide: 17% total body weight loss Tirzepatide alone: 14% or 35% less 45% of HRT users achieved 20% weight loss vs

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Statistical analysis for phase 1 clinical study The sample size of up to eight participants per cohort for this SAD and MAD trial was based on conventional study designs for FIH exploratory trials to obtain adequate safety, tolerability and PK data