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Conversely, individuals eating calorie-dense ultra-processed foods alongside tirzepatide may lose less weight because the medication works best when paired with whole foods that satisfy the reduced appetite

Also, there are nerves in the gut which can sense GLP-1 and signal back to the brain, so the picture is a lot more complicated and more research is being carried out into the way GLP-1 and GLP-1 mimetics work

Guglielmi O, Lanteri P, Garbarino S