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POMC is processed into alpha- melanocyte-stimulating hormone (-MSH) , which binds to melanocortin receptors and exerts anorexigenic effects

Holst JJ, rskov C, Nielsen OV, Schwartz TW

Protection against radiation oxidative damage in mice by Triphala

For severely obese people, the National Institutes of Health (NIH) recognizes bariatric surgery as the only effective treatment for maintaining long-term weight loss for individuals who had no success with diet, exercise and other common weight-loss strategies

Patients also reported feeling tired or week which may be a consequence of reduced calorie intake in addition to the action of the drug on the body and any side effects