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The most common side effects of Topiramate include: Tingling of the arms and legs (paresthesia) Not feeling hungry Nausea A change in the way foods taste Diarrhea Weight loss Nervousness Upper respiratory tract infection Speech problems Tiredness Dizziness Sleepiness/drowsiness Slow reactions Difficulty with memory Pain in the abdomen Fever Abnormal vision Decreased feeling or sensitivity, especially in the skin You are encouraged to report negative side effects of prescription drugs to the FDA

doi: 10.1038/s41584-020-00533-7 56 D'AdamoSCetrulloSGuidottiSSilvestriYMinguzziMSantiSet al

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One study demonstrated that less than a third individuals achieved greater than 5% weight loss during the three-year study period and only 25% of these individuals were able to maintain greater than 5% weight loss

The flux through pathways that require nonesterified CoA, such as the oxidation of glucose, may be reduced if all the CoA available in a given cell compartment is esterified