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Building evidence, including the current study, suggests that mitochondria mediated metabolite disturbances are emerging as prevalent feature in ALS, and restoration of NAD + levels by NAD+ precursor compounds could in fact be a potential therapeutic strategy for improving neuron health

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Environmentally relevant concentrations of ibuprofen (500 g/L) and microplastics (10 g/L) were chosen to represent concentrations commonly detected in contaminated aquatic ecosystems (ibuprofen: Pharms UBA Umwelt Bundesamt, 2024