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Furthermore, CsA and tacrolimus are associated with promoting direct vasoconstriction by one or more of the following mechanisms: increased tone of vascular smooth muscle (128, 150, 151), reduced nitric oxide production (129), and activation of endothelin-1 receptor (129)
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Maintain blood pressure levels
This deficiency occurs most often in older adults or those eating a vegan diet in whom a B12 deficiency is more common
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