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Tirzepatide (highest doses in SURMOUNT-1) produced average losses near or above 20%, depending on dose, with clear dose-response effects in pivotal trials

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This dual agonist represents a significant advancement in incretin-based therapies, offering enhanced metabolic benefits compared to selective GLP-1 receptor agonists

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While no absolute contraindication exists, stacking injectables increases the risk of electrolyte imbalance and gastrointestinal upset