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Further, the results obtained from BIOVIA Discovery Studio Visualizer 4.5, shown in Table 4, revealed several key amino acid residues contributing to stable ligandreceptor binding [36]

In conclusion, loss of the BBB integrity, caused by the damage of any of its specific cellular component, leads to its functional failure and in turn to cerebrovascular dysfunction, neuroinflammation and neurodegeneration, contributing also to AD development (Desai et al., 2007

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