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Reports in the Wegovy and migraine discussion on Reddit are personal experiences and cannot establish cause and effect

Data on treatment de-escalation, switching and discontinuation in older people with MS are a major unmet need, and dedicated studies should be designed to assess these strategies by use of non-inferiority frameworks and patient-preference trials, particularly in the context of real-world practice

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This review synthesizes evidence across key mechanistic domains, including endothelial dysfunction, inflammatory signaling, oxidative stress pathways, plaque biology, extracellular matrix remodeling, and immune-cell modulation

Clinical correlation can be very helpful in these cases