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If calorie intake remains the same as when you started treatment, progress may slow or stall
One important unresolved issue is the limited evidence regarding concomitant use of SGLT2 inhibitors and GLP-1 receptor agonists, a gap also acknowledged in European Society of Cardiology guidelines and Current guidelines prioritize SGLT2 inhibitors in patients with T2DM who have HF, chronic kidney disease, or elevated cardiovascular risk, while GLP-1 receptor agonists are emphasized for patients with obesity or established atherosclerotic cardiovascular disease [7]
Research suggests that GLP-1 receptor activation has neuroprotective effects and can reduce inflammation in the brain, which is linked to depression
Orforglipron Orforglipron , sold under the brand name Foundayo , is an oral, non-peptide, small-molecule GLP-1 receptor agonist developed as a weight loss drug by Eli Lilly and Company