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In order to investigate if the substrate binding protein of Gsi (GsiB) transfers GSH to Opp or vice versa (OppA to Gsi), we generated GSH-deficient cells lacking either OppA and GsiC or GsiB and OppC and expressed Grx1-roGFP2 in the resulting gshA gsiB oppC and gshA oppA gsiC triple mutants (see Figure 7 A for a schematic overview)
BMJ Open 11 , e047993 (2021)
It supports detoxification by helping the liver neutralize harmful substances
Adv Sci (Weinh) 2022;9:e2104759.PubMed 83
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