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7779 Furthermore, a recent report demonstrated that exogenous GSH at physiological concentration (10 mM) enhanced susceptibility to chloramphenicol, novobiocin, and tetracycline, while decreasing susceptibility to ciprofloxacin, erythromycin, and kanamycin in A
However, low to moderate levels of ROS can promote cancer cell survival and metastasis pathways through DNA damage-induced genomic instability, epigenetic regulation, metabolic reprogramming, and generation of pro-inflammatory and pro-tumorigenic microenvironment in a context-dependent manner [8, 12, 13, 26]
Among pharmacological approaches, positive allosteric modulation of AMPA receptors using AMPAkines (e.g., aniracetam, CX516) has shown promise
NAC serves as a precursor to cysteine, which is a limiting substrate for the synthesis of glutathione
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